[A Case of Fanconi Syndrome Induced by Zoledronic Acid in a Metastatic Colorectal Cancer Patient].
Gan To Kagaku Ryoho
; 42(7): 867-70, 2015 Jul.
Article
en Ja
| MEDLINE
| ID: mdl-26197752
ABSTRACT
A 60s-year-old woman with metastatic colorectal cancer was treated using mFOLFOX6 plus bevacizumab. Zoledronic acid was also administered owing to the presence of bone metastasis. The patient was admitted to our hospital with progressive hypokalemia, hypocalcemia, hypophosphatemia, and proximal renal tubular dysfunction. A diagnosis of Fanconi syndrome was made, and was believed to be induced by zoledronic acid treatment. This treatment was discontinued, and the patient's renal tubular function recovered. Denosumab was subsequently administered to treat the bone metastasis, and no renal tubular dysfunction occurred. It was possible to continue chemotherapy, and a complete response was obtained. Fanconi syndrome induced by zoledronic acid is rare, but it may hinder chemotherapy. Therefore, monitoring renal tubular function is recommended during therapy with zoledronic acid.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Óseas
/
Neoplasias Colorrectales
/
Difosfonatos
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Conservadores de la Densidad Ósea
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Síndrome de Fanconi
/
Imidazoles
Límite:
Female
/
Humans
Idioma:
Ja
Revista:
Gan To Kagaku Ryoho
Año:
2015
Tipo del documento:
Article
Pais de publicación:
JAPAN
/
JAPON
/
JAPÃO
/
JP