IL-10 producing B cells partially restore E2-mediated protection against EAE in PD-L1 deficient mice.
J Neuroimmunol
; 285: 129-36, 2015 Aug 15.
Article
en En
| MEDLINE
| ID: mdl-26198929
ABSTRACT
Women with multiple sclerosis (MS) often experience clinical improvement during pregnancy, indicating that sex hormones might have therapeutic effects in MS. Our previous studies have demonstrated that B cells and PD-L1 are crucial for E2 (17ß-estradiol)-mediated protection against experimental autoimmune encephalomyelitis (EAE). We here demonstrate that the transfer of IL-10(+) B cells into E2-treated PD-L1(-/-) mice after EAE induction could partially restore E2-mediated protection and decrease the frequency of pro-inflammatory cells in the CNS compared to E2/saline treated PD-L1(-/-) mice. Hence, co-administration of IL-10(+) B cells and E2 might have a powerful therapeutic potential for treatment of EAE.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Linfocitos B
/
Interleucina-10
/
Encefalomielitis Autoinmune Experimental
/
Estradiol
/
Antígeno B7-H1
Límite:
Animals
Idioma:
En
Revista:
J Neuroimmunol
Año:
2015
Tipo del documento:
Article