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5-hydroxytryptamine receptor (5-HT1DR) promotes colorectal cancer metastasis by regulating Axin1/ß-catenin/MMP-7 signaling pathway.
Sui, Hua; Xu, Hanchen; Ji, Qing; Liu, Xuan; Zhou, Lihong; Song, Haiyan; Zhou, Xiqiu; Xu, Yangxian; Chen, Zhesheng; Cai, Jianfeng; Ji, Guang; Li, Qi.
Afiliación
  • Sui H; Department of Medical Oncology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
  • Xu H; Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Chinese Medicine, Shanghai 200032, China.
  • Ji Q; Department of Medical Oncology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
  • Liu X; Department of Medical Oncology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
  • Zhou L; Department of Medical Oncology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
  • Song H; Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Chinese Medicine, Shanghai 200032, China.
  • Zhou X; Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Chinese Medicine, Shanghai 200032, China.
  • Xu Y; Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Chinese Medicine, Shanghai 200032, China.
  • Chen Z; Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY 11439, USA.
  • Cai J; Department of Chemistry, University of South Florida, Tampa, FL 33620, USA.
  • Ji G; Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Chinese Medicine, Shanghai 200032, China.
  • Li Q; Department of Medical Oncology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Oncotarget ; 6(28): 25975-87, 2015 Sep 22.
Article en En | MEDLINE | ID: mdl-26214021
ABSTRACT
Overexpression of 5-hydroxytryptamine (5-HT) in human cancer contributes to tumor metastasis, but the role of 5-HT receptor family in cancer has not been thoroughly explored. Here, we report overexpression of 5-HT(1D) receptor (5-HT(1D)R) was associated with Wnt signaling pathway and advanced tumor stage. The underlying mechanism of 5-HT(1D)R-promoted tumor invasion was through its activation on the Axin1/ß-catenin/MMP-7 pathway. In an orthotopic colorectal cancer mouse model, we demonstrated that a 5-HT(1D)R antagonist (GR127935) effectively inhibited tumor metastasis through targeting Axin1. Furthermore, in intestinal epithelium cells, we observed that 5-HT(1D)R played an important role in cell invasion via Axin1/ß-catenin/MMP-7 pathway. Together, our findings reveal an essential role of the physiologic level of 5-HT(1D)R in pulmonary metastasis of colorectal cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Metaloproteinasa 7 de la Matriz / Receptor de Serotonina 5-HT1D / Beta Catenina / Proteína Axina Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Oncotarget Año: 2015 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Metaloproteinasa 7 de la Matriz / Receptor de Serotonina 5-HT1D / Beta Catenina / Proteína Axina Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Oncotarget Año: 2015 Tipo del documento: Article País de afiliación: China