An exploratory association study of the influence of noradrenergic genes and childhood trauma in Borderline Personality Disorder.
Psychiatry Res
; 229(1-2): 589-92, 2015 Sep 30.
Article
en En
| MEDLINE
| ID: mdl-26216165
ABSTRACT
This study investigated the possible association of 40 polymorphisms within 4 noradrenergic genes with BPD risk and the modulating effect of childhood trauma on these associations in 481 BPD subjects and 442 controls. COMT rs5993882, DBH rs77905 and SLC6A2 rs1814270 showed associations with BPD, which were modulated by childhood trauma. However, none of these findings survived Bonferroni correction. Further investigation is needed to clarify the involvement of these genes in BPD pathogenesis.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trastorno de Personalidad Limítrofe
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Catecol O-Metiltransferasa
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Maltrato a los Niños
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Proteínas de Transporte de Noradrenalina a través de la Membrana Plasmática
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Estudios de Asociación Genética
Tipo de estudio:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Child
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Psychiatry Res
Año:
2015
Tipo del documento:
Article
