Positive and Negative Allosteric Modulation of an &#945;1ß3Î³2 Î³-Aminobutyric Acid Type A (GABAA) Receptor by Binding to a Site in the Transmembrane Domain at the Î³+-ß- Interface.

Jayakar, Selwyn S; Zhou, Xiaojuan; Savechenkov, Pavel Y; Chiara, David C; Desai, Rooma; Bruzik, Karol S; Miller, Keith W; Cohen, Jonathan B

Positive and Negative Allosteric Modulation of an α1ß3Î³2 Î³-Aminobutyric Acid Type A (GABAA) Receptor by Binding to a Site in the Transmembrane Domain at the Î³+-ß- Interface.

Jayakar, Selwyn S; Zhou, Xiaojuan; Savechenkov, Pavel Y; Chiara, David C; Desai, Rooma; Bruzik, Karol S; Miller, Keith W; Cohen, Jonathan B.

Afiliación

Jayakar SS; From the Departments of Neurobiology and.
Zhou X; the Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, and.
Savechenkov PY; the Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois 60612.
Chiara DC; From the Departments of Neurobiology and.
Desai R; the Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, and.
Bruzik KS; the Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois 60612.
Miller KW; the Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, and Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115.
Cohen JB; From the Departments of Neurobiology and jonathan_cohen@hms.harvard.edu.

J Biol Chem ; 290(38): 23432-46, 2015 Sep 18.

Article en En | MEDLINE | ID: mdl-26229099

Asunto(s)

Receptores de GABA-A/química; Receptores de GABA-A/metabolismo; Ácido gamma-Aminobutírico/farmacología; Regulación Alostérica/efectos de los fármacos; Regulación Alostérica/genética; Células HEK293; Humanos; Estructura Terciaria de Proteína; Receptores de GABA-A/genética

Palabras clave

Cys loop receptor; GABA receptor; allosteric regulation; anesthesia; homology modeling; photoaffinity labeling

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de GABA-A / Ácido gamma-Aminobutírico Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Biol Chem Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos

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