Interleukin-17 is involved in orthodontically induced inflammatory root resorption in dental pulp cells.
Am J Orthod Dentofacial Orthop
; 148(2): 302-9, 2015 Aug.
Article
en En
| MEDLINE
| ID: mdl-26232839
ABSTRACT
INTRODUCTION:
The objectives of this study were (1) to investigate the expressions of interleukin (IL)-17, RANKL (the receptor activator of NF-kappaB ligand), and osteoprotegerin (OPG) in root resorption areas during experimental tooth movement in rats, and (2) to determine the effect of IL-17 on the expressions of RANKL and OPG mRNA from human dental pulp cells.METHODS:
Twelve male 6-week-old Wistar rats were subjected to an orthodontic force of 50 g to induce a mesially tipping movement of the maxillary first molars for 7 days. The expression levels of tartrate resistant acid phosphatase (TRAP), interleukin (IL)-17, IL-17 receptor (IL-17R), receptor activator of nuclear factor-kappa B ligand (RANKL), and OPG proteins were determined in dental pulp by immunohistochemical analysis. Furthermore, the effects of IL-17 on the expressions of RANKL and OPG mRNA were investigated using human dental pulp cells in vitro.RESULTS:
In the experimental tooth movements in vivo, resorption lacunae with multinucleated cells were observed in the 50-g group. The immunoreactivities for IL-17, IL-17R, and RANKL were detected in dental pulp tissues subjected to the orthodontic force on day 7. Moreover, IL-17 increased the mRNA expression of RANKL from human dental pulp cells in vitro.CONCLUSIONS:
The results of this study suggest that IL-17 and RANKL may be involved in the process of orthodontically induced inflammatory root resorption in dental pulp cells.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Resorción Radicular
/
Técnicas de Movimiento Dental
/
Interleucina-17
/
Ligando RANK
/
Osteoprotegerina
Límite:
Adolescent
/
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Am J Orthod Dentofacial Orthop
Asunto de la revista:
ODONTOLOGIA
/
ORTODONTIA
Año:
2015
Tipo del documento:
Article
País de afiliación:
Japón