Structure of GTP-specific succinyl-CoA synthetase in complex with CoA.

Pig GTP-specific succinyl-CoA synthetase is an αß-heterodimer. The crystal structure of the complex with the substrate CoA was determined at 2.1 Šresolution. The structure shows CoA bound to the amino-terminal domain of the α-subunit, with the free thiol extending from the adenine portion into the site where the catalytic histidine residue resides.