[Experimental pharmacologic and morphologic study of new platinum complexes]. / Eksperimentalno-farmakologichno i morfologichno izsledvane na novi platinovi kompleksi.

ABSTRACT

Antineoplastic and toxic properties of two newly synthesized complexes of platinum (II)--with isovaleric acid and with cystine, were studied on mice with ascitic tumour of Ehrlich. The studies were compared with cis-diaminodichloroplatinum (II) (cisplatinum). Data were obtained for high antineoplastic activity and inhibiting influence of the synthesis of DNA of cisplatinum. There was therapeutic effect on the animals with ascitic tumour of Ehrlich after usage of cisplatinum. There was therapeutic effect on the animals with ascitic tumour of Ehrlich after usage of the complex of platinum with isovaleric acid and no effect after application of the complex with cystine. Information was obtained by histological examination for reduction in organic toxicity of the newly synthesized compounds against renal tissue. The necessity from multiple parametric strategy of the experiment, creating a possibility for logic direction of the investigation according to the aim-search for metallic complexes with reduced toxicity, is confirmed by the conducted study.