Direct hippocampal injection of pseudo lentivirus-delivered nerve growth factor gene rescues the damaged cognitive function after traumatic brain injury in the rat.

Lin, Yong; Wan, Jie-qing; Gao, Guo-yi; Pan, Yao-hua; Ding, Sheng-hao; Fan, Yi-ling; Wang, Yong; Jiang, Ji-yao

Lin, Yong; Wan, Jie-qing; Gao, Guo-yi; Pan, Yao-hua; Ding, Sheng-hao; Fan, Yi-ling; Wang, Yong; Jiang, Ji-yao.

Afiliación

Lin Y; Department of Neurological Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai 200127, PR China.
Wan JQ; Department of Neurological Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai 200127, PR China.
Gao GY; Department of Neurological Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai 200127, PR China.
Pan YH; Department of Neurological Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai 200127, PR China.
Ding SH; Department of Neurological Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai 200127, PR China.
Fan YL; Department of Neurological Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai 200127, PR China.
Wang Y; Department of Neurological Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai 200127, PR China.
Jiang JY; Department of Neurological Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai 200127, PR China. Electronic address: jiyaojiang@126.com.

Biomaterials ; 69: 148-57, 2015 Nov.

Article en En | MEDLINE | ID: mdl-26285082

Asunto(s)

Lesiones Encefálicas/genética; Lesiones Encefálicas/terapia; Cognición; Terapia Genética; Hipocampo/fisiopatología; Lentivirus/genética; Factor de Crecimiento Nervioso/genética; Animales; Lesiones Encefálicas/fisiopatología; Expresión Génica; Técnicas de Transferencia de Gen; Hipocampo/metabolismo; Humanos; Masculino; Neuritas/metabolismo; Neuritas/patología; Neurogénesis; Ratas; Ratas Sprague-Dawley; Transducción Genética

Palabras clave

Gene; Hippocampus; Nerve growth factor; Pseudo lentivirus; Traumatic brain injury

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lesiones Encefálicas / Terapia Genética / Cognición / Lentivirus / Factor de Crecimiento Nervioso / Hipocampo Límite: Animals / Humans / Male Idioma: En Revista: Biomaterials Año: 2015 Tipo del documento: Article

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