Your browser doesn't support javascript.
loading
Genetic Determinants of Unruptured Intracranial Aneurysms in the General Population.
Peymani, Abbas; Adams, Hieab H H; Cremers, Lotte G M; Krestin, Gabriel; Hofman, Albert; van Duijn, Cornelia M; Uitterlinden, André G; van der Lugt, Aad; Vernooij, Meike W; Ikram, M Arfan.
Afiliación
  • Peymani A; From the Departments of Epidemiology (A.P., H.H.H.A., L.G.M.C., A.H., C.M.v.D., A.G.U., M.W.V., M.A.I.), Neurology (M.A.I.), Radiology (H.H.H.A., L.G.M.C., G.K., A.v.d.L., M.W.V., M.A.I.), and Internal Medicine (A.G.U.), Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Adams HH; From the Departments of Epidemiology (A.P., H.H.H.A., L.G.M.C., A.H., C.M.v.D., A.G.U., M.W.V., M.A.I.), Neurology (M.A.I.), Radiology (H.H.H.A., L.G.M.C., G.K., A.v.d.L., M.W.V., M.A.I.), and Internal Medicine (A.G.U.), Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Cremers LG; From the Departments of Epidemiology (A.P., H.H.H.A., L.G.M.C., A.H., C.M.v.D., A.G.U., M.W.V., M.A.I.), Neurology (M.A.I.), Radiology (H.H.H.A., L.G.M.C., G.K., A.v.d.L., M.W.V., M.A.I.), and Internal Medicine (A.G.U.), Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Krestin G; From the Departments of Epidemiology (A.P., H.H.H.A., L.G.M.C., A.H., C.M.v.D., A.G.U., M.W.V., M.A.I.), Neurology (M.A.I.), Radiology (H.H.H.A., L.G.M.C., G.K., A.v.d.L., M.W.V., M.A.I.), and Internal Medicine (A.G.U.), Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Hofman A; From the Departments of Epidemiology (A.P., H.H.H.A., L.G.M.C., A.H., C.M.v.D., A.G.U., M.W.V., M.A.I.), Neurology (M.A.I.), Radiology (H.H.H.A., L.G.M.C., G.K., A.v.d.L., M.W.V., M.A.I.), and Internal Medicine (A.G.U.), Erasmus University Medical Center, Rotterdam, The Netherlands.
  • van Duijn CM; From the Departments of Epidemiology (A.P., H.H.H.A., L.G.M.C., A.H., C.M.v.D., A.G.U., M.W.V., M.A.I.), Neurology (M.A.I.), Radiology (H.H.H.A., L.G.M.C., G.K., A.v.d.L., M.W.V., M.A.I.), and Internal Medicine (A.G.U.), Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Uitterlinden AG; From the Departments of Epidemiology (A.P., H.H.H.A., L.G.M.C., A.H., C.M.v.D., A.G.U., M.W.V., M.A.I.), Neurology (M.A.I.), Radiology (H.H.H.A., L.G.M.C., G.K., A.v.d.L., M.W.V., M.A.I.), and Internal Medicine (A.G.U.), Erasmus University Medical Center, Rotterdam, The Netherlands.
  • van der Lugt A; From the Departments of Epidemiology (A.P., H.H.H.A., L.G.M.C., A.H., C.M.v.D., A.G.U., M.W.V., M.A.I.), Neurology (M.A.I.), Radiology (H.H.H.A., L.G.M.C., G.K., A.v.d.L., M.W.V., M.A.I.), and Internal Medicine (A.G.U.), Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Vernooij MW; From the Departments of Epidemiology (A.P., H.H.H.A., L.G.M.C., A.H., C.M.v.D., A.G.U., M.W.V., M.A.I.), Neurology (M.A.I.), Radiology (H.H.H.A., L.G.M.C., G.K., A.v.d.L., M.W.V., M.A.I.), and Internal Medicine (A.G.U.), Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Ikram MA; From the Departments of Epidemiology (A.P., H.H.H.A., L.G.M.C., A.H., C.M.v.D., A.G.U., M.W.V., M.A.I.), Neurology (M.A.I.), Radiology (H.H.H.A., L.G.M.C., G.K., A.v.d.L., M.W.V., M.A.I.), and Internal Medicine (A.G.U.), Erasmus University Medical Center, Rotterdam, The Netherlands. m.a.ikram@erasmu
Stroke ; 46(10): 2961-4, 2015 Oct.
Article en En | MEDLINE | ID: mdl-26286545
BACKGROUND AND PURPOSE: Genome-wide association studies have identified single-nucleotide polymorphisms (SNPs) for intracranial aneurysms in clinical samples. In addition, SNPs have been discovered for blood pressure, one of the strongest risk factors for intracranial aneurysms. We studied the role of these genetic variants on occurrence and size of unruptured intracranial aneurysms, discovered incidentally in a general community-dwelling population. METHODS: In 4890 asymptomatic participants from the Rotterdam Study, 120 intracranial aneurysms were identified on brain imaging and segmented for maximum diameter and volume. Genetic risk scores (GRS) were calculated for intracranial aneurysms (10 SNPs), systolic blood pressure (33 SNPs), and diastolic blood pressure (41 SNPs). RESULTS: The GRS for intracranial aneurysms was not statistically significantly associated with presence of aneurysms in this population (OR, 1.16; 95% CI, 0.96-1.40; P=0.119), but showed a significant association with both maximum diameter (difference in log-transformed mm per SD increase of GRS, 0.10; 95% CI, 0.02-0.19; P=0.018) and volume (difference in log-transformed µL per SD increase of GRS, 0.21; 95% CI, 0.01-0.41; P=0.040) of aneurysms. GRSs for blood pressures were associated with neither presence nor size of aneurysms. CONCLUSIONS: Genetic variants previously identified for intracranial aneurysms in clinical studies relate to the size rather than the presence of incidentally discovered, unruptured intracranial aneurysms in the general population.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Presión Sanguínea / Aneurisma Intracraneal Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Stroke Año: 2015 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Presión Sanguínea / Aneurisma Intracraneal Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Stroke Año: 2015 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos