Simple accurate mathematical models of blood HbO2 and HbCO2 dissociation curves at varied physiological conditions: evaluation and comparison with other models.
Eur J Appl Physiol
; 116(1): 97-113, 2016 Jan.
Article
en En
| MEDLINE
| ID: mdl-26298270
ABSTRACT
PURPOSE:
Equations for blood oxyhemoglobin (HbO2) and carbaminohemoglobin (HbCO2) dissociation curves that incorporate nonlinear biochemical interactions of oxygen and carbon dioxide with hemoglobin (Hb), covering a wide range of physiological conditions, are crucial for a number of practical applications. These include the development of physiologically-based computational models of alveolar-blood and blood-tissue O2CO2 transport, exchange, and metabolism, and the analysis of clinical and in vitro data. METHODS ANDRESULTS:
To this end, we have revisited, simplified, and extended our previous models of blood HbO2 and HbCO2 dissociation curves (Dash and Bassingthwaighte, Ann Biomed Eng 3816831701, 2010), validated wherever possible by available experimental data, so that the models now accurately fit the low HbO2 saturation (SHbO2) range over a wide range of values of PCO2, pH, 2,3-DPG, and temperature. Our new equations incorporate a novel PO2-dependent variable cooperativity hypothesis for the binding of O2 to Hb, and a new equation for P50 of O2 that provides accurate shifts in the HbO2 and HbCO2 dissociation curves over a wide range of physiological conditions. The accuracy and efficiency of these equations in computing PO2 and PCO2 from the SHbO2 and SHbCO2 levels using simple iterative numerical schemes that give rapid convergence is a significant advantage over alternative SHbO2 and SHbCO2 models.CONCLUSION:
The new SHbO2 and SHbCO2 models have significant computational modeling implications as they provide high accuracy under non-physiological conditions, such as ischemia and reperfusion, extremes in gas concentrations, high altitudes, and extreme temperatures.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oxígeno
/
Temperatura
/
Hemoglobinas
/
Oxihemoglobinas
/
Dióxido de Carbono
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Eur J Appl Physiol
Asunto de la revista:
FISIOLOGIA
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos