A Phase I proof-of-concept and safety trial of sildenafil to treat cerebral vasospasm following subarachnoid hemorrhage.

Washington, Chad W; Derdeyn, Colin P; Dhar, Rajat; Arias, Eric J; Chicoine, Michael R; Cross, DeWitte T; Dacey, Ralph G; Han, Byung Hee; Moran, Christopher J; Rich, Keith M; Vellimana, Ananth K; Zipfel, Gregory J

Washington, Chad W; Derdeyn, Colin P; Dhar, Rajat; Arias, Eric J; Chicoine, Michael R; Cross, DeWitte T; Dacey, Ralph G; Han, Byung Hee; Moran, Christopher J; Rich, Keith M; Vellimana, Ananth K; Zipfel, Gregory J.

Afiliación

Washington CW; Departments of 1 Neurological Surgery.
Derdeyn CP; Radiology, Washington University School of Medicine, Saint Louis, Missouri.
Dhar R; Departments of 1 Neurological Surgery.
Arias EJ; Radiology, Washington University School of Medicine, Saint Louis, Missouri.
Chicoine MR; Neurology, and.
Cross DT; Departments of 1 Neurological Surgery.
Dacey RG; Departments of 1 Neurological Surgery.
Han BH; Departments of 1 Neurological Surgery.
Moran CJ; Radiology, Washington University School of Medicine, Saint Louis, Missouri.
Rich KM; Departments of 1 Neurological Surgery.
Vellimana AK; Departments of 1 Neurological Surgery.
Zipfel GJ; Departments of 1 Neurological Surgery.

J Neurosurg ; 124(2): 318-27, 2016 Feb.

Article en En | MEDLINE | ID: mdl-26314998

Asunto(s)

Citrato de Sildenafil/uso terapéutico; Hemorragia Subaracnoidea/complicaciones; Vasodilatadores/uso terapéutico; Vasoespasmo Intracraneal/tratamiento farmacológico; Vasoespasmo Intracraneal/etiología; Administración Intravenosa; Adulto; Anciano; Anciano de 80 o más Años; Presión Arterial/efectos de los fármacos; Angiografía Cerebral; Relación Dosis-Respuesta a Droga; Femenino; Humanos; Angiografía por Resonancia Magnética; Masculino; Persona de Mediana Edad; Estudios Prospectivos; Citrato de Sildenafil/administración & dosificación; Citrato de Sildenafil/efectos adversos; Resultado del Tratamiento; Vasodilatadores/administración & dosificación; Vasodilatadores/efectos adversos

Palabras clave

CVS = cerebrovascular vasospasm; DCI = delayed cerebral ischemia; DSA = digital subtraction angiography; DSMB = Data Safety Monitoring Board; ICA = internal carotid artery; ICP = intracranial pressure; MAP = mean arterial pressure; MCA = middle cerebral artery; NNICU = Neurology/Neurosurgery ICU; NO = nitric oxide; PDE-V = phosphodiesterase-V; SAH = subarachnoid hemorrhage; aneurysm; cGMP = cyclic guanosine monophosphate; cerebral vasospasm; delayed cerebral ischemia; eNOS = endothelial nitric oxide synthase; subarachnoid hemorrhage; vascular disorders

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hemorragia Subaracnoidea / Vasodilatadores / Vasoespasmo Intracraneal / Citrato de Sildenafil Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Neurosurg Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos

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