Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing Aß Generation and Amyloid Plaque Pathogenesis.

Xiao, Qingli; Yan, Ping; Ma, Xiucui; Liu, Haiyan; Perez, Ronaldo; Zhu, Alec; Gonzales, Ernesto; Tripoli, Danielle L; Czerniewski, Leah; Ballabio, Andrea; Cirrito, John R; Diwan, Abhinav; Lee, Jin-Moo

Xiao, Qingli; Yan, Ping; Ma, Xiucui; Liu, Haiyan; Perez, Ronaldo; Zhu, Alec; Gonzales, Ernesto; Tripoli, Danielle L; Czerniewski, Leah; Ballabio, Andrea; Cirrito, John R; Diwan, Abhinav; Lee, Jin-Moo.

Afiliación

Xiao Q; Department of Neurology and the Hope Center for Neurological Disorders.
Yan P; Department of Neurology and the Hope Center for Neurological Disorders.
Ma X; Center for Cardiovascular Research in Department of Medicine, and John Cochran VA Medical Center, St. Louis, Missouri 63108, and.
Liu H; Center for Cardiovascular Research in Department of Medicine, and John Cochran VA Medical Center, St. Louis, Missouri 63108, and.
Perez R; Department of Neurology and the Hope Center for Neurological Disorders.
Zhu A; Department of Neurology and the Hope Center for Neurological Disorders.
Gonzales E; Department of Neurology and the Hope Center for Neurological Disorders.
Tripoli DL; Department of Neurology and the Hope Center for Neurological Disorders.
Czerniewski L; Department of Neurology and the Hope Center for Neurological Disorders.
Ballabio A; Telethon Institute of Genetics and Medicine, Pozzuoli, Naples, Italy 80078.
Cirrito JR; Department of Neurology and the Hope Center for Neurological Disorders.
Diwan A; Center for Cardiovascular Research in Department of Medicine, and Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri 63110, John Cochran VA Medical Center, St. Louis, Missouri 63108, and leejm@wustl.edu adiwan@dom.wustl.edu.
Lee JM; Department of Neurology and the Hope Center for Neurological Disorders, leejm@wustl.edu adiwan@dom.wustl.edu.

J Neurosci ; 35(35): 12137-51, 2015 Sep 02.

Article en En | MEDLINE | ID: mdl-26338325

Asunto(s)

Péptidos beta-Amiloides/metabolismo; Precursor de Proteína beta-Amiloide/metabolismo; Factores de Transcripción Básicos con Cremalleras de Leucinas y Motivos Hélice-Asa-Hélice/metabolismo; Lisosomas/metabolismo; Neuronas/metabolismo; Placa Amiloide/metabolismo; Péptidos beta-Amiloides/genética; Precursor de Proteína beta-Amiloide/genética; Animales; Factores de Transcripción Básicos con Cremalleras de Leucinas y Motivos Hélice-Asa-Hélice/genética; Encéfalo/patología; Proteínas de Unión al Calcio/metabolismo; Línea Celular Tumoral; Dependovirus/genética; Modelos Animales de Enfermedad; Regulación de la Expresión Génica/genética; Proteína Ácida Fibrilar de la Glía/metabolismo; Proteínas Fluorescentes Verdes/genética; Proteínas Fluorescentes Verdes/metabolismo; Lisosomas/genética; Lisosomas/patología; Ratones; Ratones Transgénicos; Proteínas de Microfilamentos/metabolismo; Mutación/genética; Neuroblastoma/patología; Neuronas/patología; Placa Amiloide/genética; Placa Amiloide/patología; Presenilina-1/genética

Palabras clave

Alzheimer's disease; TFEB; amyloid; amyloid precursor protein; lysosome

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos beta-Amiloides / Precursor de Proteína beta-Amiloide / Placa Amiloide / Factores de Transcripción Básicos con Cremalleras de Leucinas y Motivos Hélice-Asa-Hélice / Lisosomas / Neuronas Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals Idioma: En Revista: J Neurosci Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos

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