Preferential Budding of Vesicular Stomatitis Virus from the Basolateral Surface of Polarized Epithelial Cells Is Not Solely Directed by Matrix Protein or Glycoprotein.
J Virol
; 89(22): 11718-22, 2015 Nov.
Article
en En
| MEDLINE
| ID: mdl-26339064
ABSTRACT
Vesicular stomatitis virus has been shown to bud basolaterally, and the matrix protein, but not glycoprotein, was proposed to mediate this asymmetry. Using polarized T84 monolayers, we demonstrate that no single viral protein is sufficient for polarized budding. Particles are released from the apical and basolateral surfaces and are indistinguishable, indicating that there is no apical assembly defect. We propose that aspects of host cell polarity create a more efficient budding process at the basolateral surface.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Glicoproteínas
/
Proteínas de la Matriz Viral
/
Virus de la Estomatitis Vesicular Indiana
/
Células Epiteliales
/
Liberación del Virus
Idioma:
En
Revista:
J Virol
Año:
2015
Tipo del documento:
Article
País de afiliación:
Estados Unidos