Regulation of nebramycin biosynthesis by inorganic phosphate.
Folia Microbiol (Praha)
; 34(6): 539-41, 1989.
Article
en En
| MEDLINE
| ID: mdl-2635133
ABSTRACT
The effect of inorganic phosphate on the biosynthesis of nebramycin factors 2, 4 and 5' was studied in Streptomyces tenebrarius strain A (forming 2, 4 and 5' in natural ratios) and its mutants B (forming predominantly 2), C (forming 2 as the only major product) and D (forming predominantly 5'). In phosphate-supplemented complex media, the production of 2 in A, B and C was reduced by 20-70%, while the yields of 5' remained unchanged in A and decreased by 30-60% in B. The production of 4 increased by 50-90% in A and was fully suppressed in B. In D the biosynthesis of the three factors was inhibited completely.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fosfatos
/
Streptomyces
/
Antibacterianos
/
Nebramicina
Idioma:
En
Revista:
Folia Microbiol (Praha)
Año:
1989
Tipo del documento:
Article