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Effects of central gastrin-releasing peptide on glucose metabolism.
Jha, Pawan Kumar; Foppen, Ewout; Challet, Etienne; Kalsbeek, Andries.
Afiliación
  • Jha PK; Hypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands; Regulation of Circadian Clocks team, Institute of Cellular and Integrative Neurosciences, UPR3212, Centre National de la Recherche Scientifique (CNRS), University of Strasbourg, France; Internati
  • Foppen E; Department of Endocrinology and Metabolism, Academic Medical Center (AMC), University of Amsterdam, The Netherlands. Electronic address: e.foppen@nin.knaw.nl.
  • Challet E; Regulation of Circadian Clocks team, Institute of Cellular and Integrative Neurosciences, UPR3212, Centre National de la Recherche Scientifique (CNRS), University of Strasbourg, France; International Associated Laboratory LIA1061 Understanding the Neural Basis of Diurnality, CNRS, France and the Net
  • Kalsbeek A; Hypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands; Department of Endocrinology and Metabolism, Academic Medical Center (AMC), University of Amsterdam, The Netherlands; International Associated Laboratory LIA1061 Understanding the Neural Basis of
Brain Res ; 1625: 135-41, 2015 Nov 02.
Article en En | MEDLINE | ID: mdl-26358150
Gastrin-releasing peptide (GRP) mediated signals in the central nervous system (CNS) influence many functions associated with energy metabolism. The purpose of the present study was to investigate the central effect of GRP on glucose metabolism in the male rat. Intracerebroventricular (icv) administration of GRP caused an immediate hyperglycaemia which was sustained till the end of the infusion. The rise in plasma glucose levels was accompanied by an increase in endogenous glucose production (EGP), as well as increases in plasma glucagon and insulin concentrations. Furthermore, no differences in plasma corticosterone levels were noted between control and GRP treated rats. These results demonstrate that central GRP increases plasma glucose levels, probably by stimulating pancreatic glucagon release and concomitantly or subsequently endogenous glucose production.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glucemia / Fármacos Gastrointestinales / Péptido Liberador de Gastrina Límite: Animals / Humans / Male Idioma: En Revista: Brain Res Año: 2015 Tipo del documento: Article Pais de publicación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glucemia / Fármacos Gastrointestinales / Péptido Liberador de Gastrina Límite: Animals / Humans / Male Idioma: En Revista: Brain Res Año: 2015 Tipo del documento: Article Pais de publicación: Países Bajos