COX assembly factor ccdc56 regulates mitochondrial morphology by affecting mitochondrial recruitment of Drp1.
FEBS Lett
; 589(20 Pt B): 3126-32, 2015 Oct 07.
Article
en En
| MEDLINE
| ID: mdl-26358295
ABSTRACT
Mitochondria are dynamic organelles that alter their morphology in response to cellular signaling and differentiation through balanced fusion and fission. In this study, we found that the mitochondrial inner membrane ATPase ATAD3A interacted with ccdc56/MITRAC12/COA3, a subunit of the cytochrome oxidase (COX)-assembly complex. Overproduction of ccdc56 in HeLa cells resulted in fragmented mitochondrial morphology, while mitochondria were highly elongated in ccdc56-repressed cells by the defective recruitment of the fission factor Drp1. We also found that mild and chronic inhibition of COX led to mitochondrial elongation, as seen in ccdc56-repressed cells. These results indicate that ccdc56 positively regulates mitochondrial fission via regulation of COX activity and the mitochondrial recruitment of Drp1, and thus, suggest a novel relationship between COX assembly and mitochondrial morphology.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Mitocondriales
/
Tamaño Mitocondrial
/
GTP Fosfohidrolasas
/
Proteínas de la Membrana
/
Proteínas Asociadas a Microtúbulos
Límite:
Humans
Idioma:
En
Revista:
FEBS Lett
Año:
2015
Tipo del documento:
Article
País de afiliación:
Japón