Immune response to Hepatitis B vaccine in patients with celiac disease: A systematic review and meta-analysis.
Hum Vaccin Immunother
; 11(12): 2800-5, 2015.
Article
en En
| MEDLINE
| ID: mdl-26378476
ABSTRACT
It is debated whether patients with celiac disease (CD) have non-protective antibody responses to HBV vaccination more frequently than non-affected subjects. To perform a literature review and meta-analysis on protective response to HBV vaccination in CD patients. RCTs and observational controlled studies were eligible. Outcome of interest was an anti-HBs (HBsAb) titer ≥ 10 IU/L after last vaccine dose. Comparative index was rate ratio (RR). Heterogeneity between studies was addressed and funnel plots were analyzed. Meta-regression models were applied to investigate effect size due to study-specific variables. Twelve retrospective studies on a total of 1,447 participants and 4 prospective studies on 184 subjects were selected. The RR was 0.732 (95% C.I. 0.664-0.808) and 0.777 (95% C.I. 0.629-0.960) in the prospective and retrospective studies, respectively. The I(2), indicating heterogeneity, was 51.1% in retrospective, 39.8% in prospective studies. Non-protective antibody responses occurred more frequently in patients than controls. Due to limitations in the available studies, additional trials to evaluate post-vaccination HBsAb titer in CD patients are needed.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedad Celíaca
/
Vacunación
/
Vacunas contra Hepatitis B
/
Antígenos de Superficie de la Hepatitis B
/
Anticuerpos Antivirales
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Systematic_reviews
Límite:
Humans
Idioma:
En
Revista:
Hum Vaccin Immunother
Año:
2015
Tipo del documento:
Article
País de afiliación:
Italia