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Genetic analysis of the RELN gene: Gender specific association with Alzheimer's disease.
Fehér, Ágnes; Juhász, Anna; Pákáski, Magdolna; Kálmán, János; Janka, Zoltán.
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  • Fehér Á; Department of Psychiatry, University of Szeged, Szeged, Hungary. Electronic address: feher.agnes@med.u-szeged.hu.
  • Juhász A; Department of Psychiatry, University of Szeged, Szeged, Hungary.
  • Pákáski M; Department of Psychiatry, University of Szeged, Szeged, Hungary.
  • Kálmán J; Department of Psychiatry, University of Szeged, Szeged, Hungary.
  • Janka Z; Department of Psychiatry, University of Szeged, Szeged, Hungary.
Psychiatry Res ; 230(2): 716-8, 2015 Dec 15.
Article en En | MEDLINE | ID: mdl-26384575
Association between genetic variants of the reelin (RELN) gene and the risk for developing Alzheimer's disease (AD) was examined in a sample of 432 patients and 308 controls. Single marker and haplotype analyses revealed that the strongly linked rs528528 and rs607755 polymorphisms are associated with AD risk in a gender specific manner. Among men, but not in women the rs528528 T/T and rs607755 A/A genotypes were significantly associated with the susceptibility to AD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Variación Genética / Serina Endopeptidasas / Moléculas de Adhesión Celular Neuronal / Proteínas de la Matriz Extracelular / Caracteres Sexuales / Estudios de Asociación Genética / Enfermedad de Alzheimer / Proteínas del Tejido Nervioso Tipo de estudio: Prognostic_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Psychiatry Res Año: 2015 Tipo del documento: Article Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Variación Genética / Serina Endopeptidasas / Moléculas de Adhesión Celular Neuronal / Proteínas de la Matriz Extracelular / Caracteres Sexuales / Estudios de Asociación Genética / Enfermedad de Alzheimer / Proteínas del Tejido Nervioso Tipo de estudio: Prognostic_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Psychiatry Res Año: 2015 Tipo del documento: Article Pais de publicación: Irlanda