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Role of JNK and Contribution of p53 to the Realization of the Growth Potential of Mesenchymal Precursor Cells under the Effect of Fibroblast Growth Factor.
Zyuz'kov, G N; Zhdanov, V V; Udut, E V; Miroshnichenko, L A; Khrichkova, T Yu; Danilets, M G; Simanina, E V; Chaikovskii, A V; Agafonov, V I; Sherstoboev, E Yu; Minakova, M Yu; Burmina, Ya V; Udut, V V; Dygai, A M.
Afiliación
  • Zyuz'kov GN; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia. zgn@rambler.ru.G.N.Zyuz'kov.
  • Zhdanov VV; Tomsk State University, Tomsk, Russia. zgn@rambler.ru.G.N.Zyuz'kov.
  • Udut EV; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
  • Miroshnichenko LA; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
  • Khrichkova TY; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
  • Danilets MG; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
  • Simanina EV; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
  • Chaikovskii AV; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
  • Agafonov VI; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
  • Sherstoboev EY; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
  • Minakova MY; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
  • Burmina YV; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
  • Udut VV; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
  • Dygai AM; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
Bull Exp Biol Med ; 159(4): 479-81, 2015 Aug.
Article en En | MEDLINE | ID: mdl-26388570
ABSTRACT
The role of JNK-mediated signal pathway and participation of p53 transcription factor in stimulation of mesenchymal precursor cell function by the fibroblast growth factor was studied. The levels of fibroblast colony- and cluster formation and proliferative activity of mesenchymal precursors increased in response to JNK and p53 specific inhibitors. JNK and p53 blockers did not change the rate of fibroblast growth factor-induced progenitor element differentiation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína p53 Supresora de Tumor / MAP Quinasa Quinasa 4 / Células Madre Mesenquimatosas / Factores de Crecimiento de Fibroblastos Límite: Animals Idioma: En Revista: Bull Exp Biol Med Año: 2015 Tipo del documento: Article País de afiliación: Rusia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína p53 Supresora de Tumor / MAP Quinasa Quinasa 4 / Células Madre Mesenquimatosas / Factores de Crecimiento de Fibroblastos Límite: Animals Idioma: En Revista: Bull Exp Biol Med Año: 2015 Tipo del documento: Article País de afiliación: Rusia