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Chemical de-conjugation for investigating the stability of small molecule drugs in antibody-drug conjugates.
Chen, Tao; Su, Dian; Gruenhagen, Jason; Gu, Christine; Li, Yi; Yehl, Peter; Chetwyn, Nik P; Medley, Colin D.
Afiliación
  • Chen T; Small Molecule Analytical Chemistry and Quality Control, Small Molecule Pharmaceutical Sciences, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Su D; Assay Development and Technology, Bioanalytical Sciences, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Gruenhagen J; Small Molecule Analytical Chemistry and Quality Control, Small Molecule Pharmaceutical Sciences, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Gu C; Small Molecule Analytical Chemistry and Quality Control, Small Molecule Pharmaceutical Sciences, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Li Y; Small Molecule Analytical Chemistry and Quality Control, Small Molecule Pharmaceutical Sciences, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Yehl P; Small Molecule Analytical Chemistry and Quality Control, Small Molecule Pharmaceutical Sciences, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Chetwyn NP; Small Molecule Analytical Chemistry and Quality Control, Small Molecule Pharmaceutical Sciences, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Medley CD; Small Molecule Analytical Chemistry and Quality Control, Small Molecule Pharmaceutical Sciences, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States. Electronic address: medley.colin@gene.com.
J Pharm Biomed Anal ; 117: 304-10, 2016 Jan 05.
Article en En | MEDLINE | ID: mdl-26406314
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Química Farmacéutica / Inmunoconjugados / Anticuerpos Monoclonales Humanizados Límite: Humans Idioma: En Revista: J Pharm Biomed Anal Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Química Farmacéutica / Inmunoconjugados / Anticuerpos Monoclonales Humanizados Límite: Humans Idioma: En Revista: J Pharm Biomed Anal Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido