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An ex vivo potency assay to assess active drug levels of a GLP-1 agonistic peptide during preclinical safety studies.
Schäfer, Martin; Challand, Steven; Schick, Eginhard; Bader, Sabine; Hainzl, Dominik; Heinig, Katja; Müller, Lutz; Papadimitriou, Apollon; Heinrich, Julia.
Afiliación
  • Schäfer M; Roche Pharmaceutical Research & Early Development, Pharmaceutical Sciences, Roche Innovation Center Penzberg, Roche Diagnostics GmbH, Nonnenwald 2, 82377 Penzberg, Germany.
  • Challand S; Roche Pharmaceutical Research & Early Development, Pharmaceutical Sciences, Roche Innovation Center Penzberg, Roche Diagnostics GmbH, Nonnenwald 2, 82377 Penzberg, Germany.
  • Schick E; Roche Pharmaceutical Research & Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, Switzerland.
  • Bader S; Roche Pharmaceutical Research & Early Development, Pharmaceutical Sciences, Roche Innovation Center Penzberg, Roche Diagnostics GmbH, Nonnenwald 2, 82377 Penzberg, Germany.
  • Hainzl D; Metabolism & Pharmacokinetics, Novartis Institute for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA 02139, USA.
  • Heinig K; Roche Pharmaceutical Research & Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, Switzerland.
  • Müller L; Roche Pharmaceutical Research & Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, Switzerland.
  • Papadimitriou A; Roche Pharmaceutical Research & Early Development, Pharmaceutical Sciences, Roche Innovation Center Penzberg, Roche Diagnostics GmbH, Nonnenwald 2, 82377 Penzberg, Germany.
  • Heinrich J; Roche Pharmaceutical Research & Early Development, Pharmaceutical Sciences, Roche Innovation Center Penzberg, Roche Diagnostics GmbH, Nonnenwald 2, 82377 Penzberg, Germany.
Bioanalysis ; 7(24): 3063-72, 2015 Dec.
Article en En | MEDLINE | ID: mdl-26440381
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Bioensayo / Cromatografía Liquida / AMP Cíclico / Péptido 1 Similar al Glucagón / Espectrometría de Masas en Tándem Límite: Animals Idioma: En Revista: Bioanalysis Año: 2015 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Bioensayo / Cromatografía Liquida / AMP Cíclico / Péptido 1 Similar al Glucagón / Espectrometría de Masas en Tándem Límite: Animals Idioma: En Revista: Bioanalysis Año: 2015 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido