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Normal mast cell numbers in the tissues of AhR-deficient mice.
Pilz, Caroline; Feyerabend, Thorsten; Sonner, Jana; Redaelli, Chiara; Peter, Katharina; Kunze, Anja; Haas, Katharina; Esser, Charlotte; Schäkel, Knut; Wick, Wolfgang; Rodewald, Hans-Reimer; Lanz, Tobias V; Platten, Michael.
Afiliación
  • Pilz C; DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Feyerabend T; Division for Cellular Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Sonner J; DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Redaelli C; DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Peter K; DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Kunze A; Department of Dermatology, University Hospital Heidelberg, Heidelberg, Germany.
  • Haas K; IUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany.
  • Esser C; IUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany.
  • Schäkel K; Department of Dermatology, University Hospital Heidelberg, Heidelberg, Germany.
  • Wick W; DKTK Clinical Cooperation Unit Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Rodewald HR; Department of Neurology, University Hospital Heidelberg and National Center for Tumor Diseases, Heidelberg, Germany.
  • Lanz TV; Division for Cellular Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Platten M; DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Exp Dermatol ; 25(1): 62-3, 2016 Jan.
Article en En | MEDLINE | ID: mdl-26443189
ABSTRACT
The transcription factor aryl hydrocarbon receptor (AhR) acts as an immunomodulatory molecule in several immune cell lineages. Recently, it has been implicated in development and maintenance of immune cells in barrier tissues such as skin and mucosa. To investigate its role on mast cell development and maintenance in skin, peritoneal exudate cells (PECs) and lymph nodes, we studied in depth their phenotype in AhR-deficient mice. Our findings do not provide any evidence for a suspected role of the AhR in mast cell homeostasis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de Hidrocarburo de Aril / Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico / Mastocitos Límite: Animals Idioma: En Revista: Exp Dermatol Asunto de la revista: DERMATOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de Hidrocarburo de Aril / Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico / Mastocitos Límite: Animals Idioma: En Revista: Exp Dermatol Asunto de la revista: DERMATOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Alemania