Your browser doesn't support javascript.
loading
A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging.
McCormick, Mark A; Delaney, Joe R; Tsuchiya, Mitsuhiro; Tsuchiyama, Scott; Shemorry, Anna; Sim, Sylvia; Chou, Annie Chia-Zong; Ahmed, Umema; Carr, Daniel; Murakami, Christopher J; Schleit, Jennifer; Sutphin, George L; Wasko, Brian M; Bennett, Christopher F; Wang, Adrienne M; Olsen, Brady; Beyer, Richard P; Bammler, Theodor K; Prunkard, Donna; Johnson, Simon C; Pennypacker, Juniper K; An, Elroy; Anies, Arieanna; Castanza, Anthony S; Choi, Eunice; Dang, Nick; Enerio, Shiena; Fletcher, Marissa; Fox, Lindsay; Goswami, Sarani; Higgins, Sean A; Holmberg, Molly A; Hu, Di; Hui, Jessica; Jelic, Monika; Jeong, Ki-Soo; Johnston, Elijah; Kerr, Emily O; Kim, Jin; Kim, Diana; Kirkland, Katie; Klum, Shannon; Kotireddy, Soumya; Liao, Eric; Lim, Michael; Lin, Michael S; Lo, Winston C; Lockshon, Dan; Miller, Hillary A; Moller, Richard M.
Afiliación
  • McCormick MA; Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.
  • Delaney JR; Department of Pathology, University of Washington, Seattle, WA 98195, USA; Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.
  • Tsuchiya M; Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.
  • Tsuchiyama S; Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.
  • Shemorry A; Department of Pathology, University of Washington, Seattle, WA 98195, USA.
  • Sim S; Department of Pathology, University of Washington, Seattle, WA 98195, USA.
  • Chou AC; Department of Pathology, University of Washington, Seattle, WA 98195, USA.
  • Ahmed U; Department of Pathology, University of Washington, Seattle, WA 98195, USA.
  • Carr D; Department of Pathology, University of Washington, Seattle, WA 98195, USA.
  • Murakami CJ; Department of Pathology, University of Washington, Seattle, WA 98195, USA.
  • Schleit J; Department of Pathology, University of Washington, Seattle, WA 98195, USA.
  • Sutphin GL; Department of Pathology, University of Washington, Seattle, WA 98195, USA; Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.
  • Wasko BM; Department of Pathology, University of Washington, Seattle, WA 98195, USA.
  • Bennett CF; Department of Pathology, University of Washington, Seattle, WA 98195, USA; Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.
  • Wang AM; Department of Pathology, University of Washington, Seattle, WA 98195, USA.
  • Olsen B; Department of Pathology, University of Washington, Seattle, WA 98195, USA.
  • Beyer RP; Department of Occupational and Environmental Health Sciences, University of Washington, Seattle, WA 98195, USA.
  • Bammler TK; Department of Occupational and Environmental Health Sciences, University of Washington, Seattle, WA 98195, USA.
  • Prunkard D; Department of Pathology, University of Washington, Seattle, WA 98195, USA.
  • Johnson SC; Department of Pathology, University of Washington, Seattle, WA 98195, USA.
  • Pennypacker JK; Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.
  • An E; Department of Pathology, University of Washington, Seattle, WA 98195, USA.
  • Anies A; Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.
  • Castanza AS; Department of Pathology, University of Washington, Seattle, WA 98195, USA.
  • Choi E; Department of Pathology, University of Washington, Seattle, WA 98195, USA.
  • Dang N; Department of Pathology, University of Washington, Seattle, WA 98195, USA.
  • Enerio S; Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.
  • Fletcher M; Department of Pathology, University of Washington, Seattle, WA 98195, USA.
  • Fox L; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  • Goswami S; Department of Pathology, University of Washington, Seattle, WA 98195, USA.
  • Higgins SA; Department of Pathology, University of Washington, Seattle, WA 98195, USA.
  • Holmberg MA; Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.
  • Hu D; Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.
  • Hui J; Department of Pathology, University of Washington, Seattle, WA 98195, USA.
  • Jelic M; Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.
  • Jeong KS; Department of Pathology, University of Washington, Seattle, WA 98195, USA.
  • Johnston E; Department of Pathology, University of Washington, Seattle, WA 98195, USA.
  • Kerr EO; Department of Pathology, University of Washington, Seattle, WA 98195, USA.
  • Kim J; Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.
  • Kim D; Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.
  • Kirkland K; Department of Pathology, University of Washington, Seattle, WA 98195, USA.
  • Klum S; Department of Pathology, University of Washington, Seattle, WA 98195, USA.
  • Kotireddy S; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  • Liao E; Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.
  • Lim M; Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.
  • Lin MS; Department of Pathology, University of Washington, Seattle, WA 98195, USA.
  • Lo WC; Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.
  • Lockshon D; Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.
  • Miller HA; Department of Pathology, University of Washington, Seattle, WA 98195, USA.
  • Moller RM; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Cell Metab ; 22(5): 895-906, 2015 Nov 03.
Article en En | MEDLINE | ID: mdl-26456335
Many genes that affect replicative lifespan (RLS) in the budding yeast Saccharomyces cerevisiae also affect aging in other organisms such as C. elegans and M. musculus. We performed a systematic analysis of yeast RLS in a set of 4,698 viable single-gene deletion strains. Multiple functional gene clusters were identified, and full genome-to-genome comparison demonstrated a significant conservation in longevity pathways between yeast and C. elegans. Among the mechanisms of aging identified, deletion of tRNA exporter LOS1 robustly extended lifespan. Dietary restriction (DR) and inhibition of mechanistic Target of Rapamycin (mTOR) exclude Los1 from the nucleus in a Rad53-dependent manner. Moreover, lifespan extension from deletion of LOS1 is nonadditive with DR or mTOR inhibition, and results in Gcn4 transcription factor activation. Thus, the DNA damage response and mTOR converge on Los1-mediated nuclear tRNA export to regulate Gcn4 activity and aging.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Proteínas de Complejo Poro Nuclear / Proteínas de Saccharomyces cerevisiae / Factores de Transcripción con Cremalleras de Leucina de Carácter Básico / Longevidad Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Cell Metab Asunto de la revista: METABOLISMO Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Proteínas de Complejo Poro Nuclear / Proteínas de Saccharomyces cerevisiae / Factores de Transcripción con Cremalleras de Leucina de Carácter Básico / Longevidad Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Cell Metab Asunto de la revista: METABOLISMO Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos