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Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic Activity.
Mori, Shogo; Williams, Howard; Cagle, Davey; Karanovich, Kristopher; Horgen, F David; Smith, Roger; Watanabe, Coran M H.
Afiliación
  • Mori S; Department of Chemistry, Texas A&M University, College Station, TX 77843, USA. smori@mail.chem.tamu.edu.
  • Williams H; Department of Chemistry, Texas A&M University, College Station, TX 77843, USA. williams@cbnmr.chem.tamu.edu.
  • Cagle D; Department of Natural Sciences, Hawaii Pacific University, Kaneohe, HI 96744, USA. dcagle@my.hpu.edu.
  • Karanovich K; Department of Natural Sciences, Hawaii Pacific University, Kaneohe, HI 96744, USA. kkaranovich@gmail.com.
  • Horgen FD; Department of Natural Sciences, Hawaii Pacific University, Kaneohe, HI 96744, USA. dhorgen@hpu.edu.
  • Smith R; Department of Veterinary Pathology, Texas A&M University, College Station, TX 77843, USA. ROSmith@cvm.tamu.edu.
  • Watanabe CM; Department of Chemistry, Texas A&M University, College Station, TX 77843, USA. watanabe@mail.chem.tamu.edu.
Mar Drugs ; 13(10): 6274-90, 2015 10 09.
Article en En | MEDLINE | ID: mdl-26473885
ABSTRACT
A new bioactive macrolactone, nuiapolide (1) was identified from a marine cyanobacterium collected off the coast of Niihau, near Lehua Rock. The natural product exhibits anti-chemotactic activity at concentrations as low as 1.3 µM against Jurkat cells, cancerous T lymphocytes, and induces a G2/M phase cell cycle shift. Structural characterization of the natural product revealed the compound to be a 40-membered macrolactone with nine hydroxyl functional groups and a rare tert-butyl carbinol residue.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quimiotaxis / Cianobacterias / Macrólidos Límite: Humans País/Región como asunto: America do norte Idioma: En Revista: Mar Drugs Asunto de la revista: BIOLOGIA / FARMACOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quimiotaxis / Cianobacterias / Macrólidos Límite: Humans País/Región como asunto: America do norte Idioma: En Revista: Mar Drugs Asunto de la revista: BIOLOGIA / FARMACOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos