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When do patients prefer a direct oral anticoagulant over a vitamin K antagonist?
Boom, M S; Berghuis, E M; Nieuwkerk, P T; Pinedo, S; Büller, H R.
Afiliación
  • Boom MS; University of Amsterdam, Academic Medical Center, Amsterdam, the Netherlands.
Neth J Med ; 73(8): 368-72, 2015 Oct.
Article en En | MEDLINE | ID: mdl-26478546
BACKGROUND: The reasons for patients to change their usual vitamin K antagonist (VKA) treatment to a direct oral anticoagulant (DOAC) are unexplored. METHOD: A random sample of 200 patients treated with VKAs for the indication of atrial fibrillation from the Thrombosis Service in Amsterdam was selected. A survey, using the treatment trade-off technique, was sent to participants. The trade-off included four scenarios: 1 (no need for laboratory controls); 2 (less bleeding); 3 (less interactions); 4 (more effective). RESULTS: Under scenario 1, 57% of the patients would have made the switch, with a further increase to 65% with scenario 2 (trend value, p = 0.006, 95% CI 1.11-1.85). In addition, in each scenario patients who were less satisfied with their current treatment were more likely to switch to a DOAC compared with satisfied patients. The variables duration of treatment, gender, age and educational level did not affect the preference for a DOAC. CONCLUSION: Patients considered no requirement for regular laboratory control and a lower risk of bleeding the most important arguments to switch to a DOAC.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vitamina K / Prioridad del Paciente / Sustitución de Medicamentos / Inhibidores del Factor Xa / Anticoagulantes Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Neth J Med Año: 2015 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Países Bajos
Buscar en Google
Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vitamina K / Prioridad del Paciente / Sustitución de Medicamentos / Inhibidores del Factor Xa / Anticoagulantes Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Neth J Med Año: 2015 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Países Bajos