Comparative analysis of CD4 and CD8 lymphocytes - evidences for different distribution in primary and secondary liver tumors.
Folia Histochem Cytobiol
; 53(3): 272-81, 2015.
Article
en En
| MEDLINE
| ID: mdl-26484587
ABSTRACT
INTRODUCTION:
The impact of tumor cells on tumor-infiltrating lymphocytes (TILs) in cancer development is not yet clarified. Our study analyzed the distribution and prognostic value of CD4+ and CD8+ T lymphocytes in hepatocellular carcinoma (HCC) and liver metastases (LM). MATERIAL ANDMETHODS:
Archival tissue specimens of 35 HCC and 39 LM patients were immunohistochemically processed. The number of intratumoral (IT) and peritumoral (PT) CD4+ and CD8+ T cells was quantitatively analyzed.RESULTS:
We noted large variances of T lymphocyte subpopulations. Similar number of CD4+ and CD8+ lym-phocytes was present in HCC, whereas in LM the number of CD8+ cells was approximately two times higher than CD4+ lymphocytes. A significant prevalence of T cells in PT over IT areas was observed. The prognostic value was demonstrated only for PT CD8+ lymphocytes in LM, their reduced number being associated with shorter survival.CONCLUSIONS:
The differences between proportions of T lymphocytes within tumor and its environment might be explained by proapoptotic effect of cancer cells on TILs.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Linfocitos T CD4-Positivos
/
Carcinoma Hepatocelular
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Linfocitos T CD8-positivos
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Neoplasias Hepáticas
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
/
Female
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Humans
/
Male
Idioma:
En
Revista:
Folia Histochem Cytobiol
Asunto de la revista:
HISTOCITOQUIMICA
Año:
2015
Tipo del documento:
Article