Anti-biofilm activity of zinc oxide and hydroxyapatite nanoparticles as dental implant coating materials.
J Dent
; 43(12): 1462-9, 2015 Dec.
Article
en En
| MEDLINE
| ID: mdl-26497232
ABSTRACT
OBJECTIVES:
Dental implants are prone to failure as a result of bacterial biofilm accumulation. Such biofilms are often resistant to traditional antimicrobials and the use of nanoparticles as implant coatings may offer a means to control infection over a prolonged period. The objective of this study was to determine the antibiofilm activity of nanoparticulate coated titanium (Ti) discs using a film fermenter based system.METHODS:
Metal oxide nanoparticles of zinc oxide (nZnO), hydroxyapatite (nHA) and a combination (nZnO+nHA) were coated using electrohydrodynamic deposition onto Ti discs. Using human saliva as an inoculum, biofilms were grown on coated discs for 96 h in a constant depth film fermenter under aerobic conditions with artificial saliva and peri-implant sulcular fluid. Viability assays and biofilm thickness measurements were used to assess antimicrobial activity.RESULTS:
Following 96 h, reduced numbers of facultatively anaerobic and Streptococcus spp. on all three nano-coated surfaces were demonstrated. The proportion of non-viable microorganisms was shown to be higher on nZnO and composite (nZnO+nHA) coated surfaces at 96 h compared with nHA coated and uncoated titanium. Biofilm thickness comparison also demonstrated that nZnO and composite coatings to be the most effective.CONCLUSIONS:
The findings support the use of coating Ti dental implant surfaces with nZnO to provide an antimicrobial function. CLINICALSIGNIFICANCE:
Current forms of treatment for implant associated infection are often inadequate and may result in chronic infection requiring implant removal and resective/regenerative procedures to restore and reshape supporting tissue. The use of metal oxide nanoparticles to coat implants could provide osteoconductive and antimicrobial functionalities to prevent failure.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Óxido de Zinc
/
Implantes Dentales
/
Durapatita
/
Biopelículas
/
Materiales Biocompatibles Revestidos
/
Nanopartículas
/
Antiinfecciosos
Límite:
Humans
Idioma:
En
Revista:
J Dent
Año:
2015
Tipo del documento:
Article
País de afiliación:
Reino Unido