Decreased severity of collagen antibody and lipopolysaccharide-induced arthritis in human IL-32ß overexpressed transgenic mice.
Oncotarget
; 6(36): 38566-77, 2015 Nov 17.
Article
en En
| MEDLINE
| ID: mdl-26497686
ABSTRACT
Interleukin (IL)-32, mainly produced by T-lymphocytes, natural killer cells, epithelial cells, and blood monocytes, is dominantly known as a pro-inflammatory cytokine. However, the role of IL-32 on inflammatory disease has been doubtful according to diverse conflicting results. This study was designed to examine the role of IL-32ß on the development of collagen antibody (CAIA) and lipopolysaccharide (LPS)-induced inflammatory arthritis. Our data showed that the paw swelling volume and clinical score were significantly reduced in the CAIA and LPS-treated IL-32ß transgenic mice compared with non-transgenic mice. The populations of cytotoxic T, NK and dendritic cells was inhibited and NF-κB and STAT3 activities were significantly lowered in the CAIA and LPS-treated IL-32ß transgenic mice. The expression of pro-inflammatory proteins was prevented in the paw tissues of CAIA and LPS-treated IL-32ß transgenic mice. In addition, IL-32ß altered several cytokine levels in the blood, spleen and paw joint. Our data indicates that IL-32ß comprehensively inhibits the inflammation responses in the CAIA and LPS-induced inflammatory arthritis model.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Artritis
/
Colágeno
/
Interleucinas
Tipo de estudio:
Prognostic_studies
Límite:
Animals
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Humans
/
Male
Idioma:
En
Revista:
Oncotarget
Año:
2015
Tipo del documento:
Article