Aging-related Increase in Rho Kinase Activity in the Nigral Region Is Counteracted by Physical Exercise.
J Gerontol A Biol Sci Med Sci
; 71(10): 1254-7, 2016 10.
Article
en En
| MEDLINE
| ID: mdl-26503374
ABSTRACT
Abnormal activation of the RhoA/Rho kinase (ROCK) pathway plays a pivotal role in neuroinflammatory and pro-oxidative responses, axonal retraction, and apoptosis. We observed increased expression of RhoA, ROCK II, and ROCK activity in the brain of aged rats, particularly in the substantia nigra. Increased ROCK activity may enhance major mechanisms responsible for aging-related neurodegeneration, thus representing a major factor in the vulnerability of dopaminergic neurons to damage. We also observed that physical exercise decreased ROCK activation in aged rats. This suggests that decreased ROCK activation plays an important role in the neuroprotective effects of exercise observed in several previous studies. Furthermore, the present results suggest that ROCK inhibitors may constitute an effective neuroprotective strategy against aging-related risk of dopaminergic degeneration and possibly against other aging-related neurodegenerative processes.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Condicionamiento Físico Animal
/
Sustancia Negra
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Apoptosis
/
Quinasas Asociadas a rho
/
Neuroprotección
Límite:
Animals
Idioma:
En
Revista:
J Gerontol A Biol Sci Med Sci
Asunto de la revista:
GERIATRIA
Año:
2016
Tipo del documento:
Article
País de afiliación:
España