Effect of summer daylight exposure and genetic background on growth in growth hormone-deficient children.
Pharmacogenomics J
; 16(6): 540-550, 2016 11.
Article
en En
| MEDLINE
| ID: mdl-26503811
ABSTRACT
The response to growth hormone in humans is dependent on phenotypic, genetic and environmental factors. The present study in children with growth hormone deficiency (GHD) collected worldwide characterised gene-environment interactions on growth response to recombinant human growth hormone (r-hGH). Growth responses in children are linked to latitude, and we found that a correlate of latitude, summer daylight exposure (SDE), was a key environmental factor related to growth response to r-hGH. In turn growth response was determined by an interaction between both SDE and genes known to affect growth response to r-hGH. In addition, analysis of associated networks of gene expression implicated a role for circadian clock pathways and specifically the developmental transcription factor NANOG. This work provides the first observation of gene-environment interactions in children treated with r-hGH.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Estaciones del Año
/
Luz Solar
/
Estatura
/
Hormona de Crecimiento Humana
/
Polimorfismo de Nucleótido Simple
/
Interacción Gen-Ambiente
/
Antecedentes Genéticos
/
Trastornos del Crecimiento
Tipo de estudio:
Clinical_trials
/
Observational_studies
/
Risk_factors_studies
Límite:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Pharmacogenomics J
Asunto de la revista:
BIOLOGIA MOLECULAR
/
FARMACOLOGIA
Año:
2016
Tipo del documento:
Article
País de afiliación:
Reino Unido