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Clinicopathologic features of breast cancers that develop in women with previous benign breast disease.
Visscher, Daniel W; Frost, Marlene H; Hartmann, Lynn C; Frank, Ryan D; Vierkant, Robert A; McCullough, Ann E; Winham, Stacey J; Vachon, Celine M; Ghosh, Karthik; Brandt, Kathleen R; Farrell, Ann M; Tarabishy, Yaman; Hieken, Tina J; Haddad, Tufia C; Kraft, Ruth A; Radisky, Derek C; Degnim, Amy C.
Afiliación
  • Visscher DW; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.
  • Frost MH; Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota.
  • Hartmann LC; Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota.
  • Frank RD; Department of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota.
  • Vierkant RA; Department of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota.
  • McCullough AE; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.
  • Winham SJ; Department of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota.
  • Vachon CM; Health Science Research, Mayo Clinic, Rochester, Minnesota.
  • Ghosh K; Department of General Internal Medicine, Mayo Clinic, Rochester, Minnesota.
  • Brandt KR; Department of Radiology, Mayo Clinic, Rochester, Minnesota.
  • Farrell AM; Library, Mayo Clinic, Rochester, Minnesota.
  • Tarabishy Y; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri.
  • Hieken TJ; Department of Surgery, Mayo Clinic, Rochester, Minnesota.
  • Haddad TC; Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota.
  • Kraft RA; Research Services, Mayo Clinic, Rochester, Minnesota.
  • Radisky DC; Division of Cancer Biology, Mayo Clinic Florida, Jacksonville, Florida.
  • Degnim AC; Department of Surgery, Mayo Clinic, Rochester, Minnesota.
Cancer ; 122(3): 378-85, 2016 Feb 01.
Article en En | MEDLINE | ID: mdl-26512815
ABSTRACT

BACKGROUND:

Women with benign breast disease (BBD) have an increased risk of developing breast cancer (BC). Nearly 30% of all BCs develop in women with prior BBD. Information regarding features of the expected number of BCs after BBD would enhance individualized surveillance and prevention strategies for these women. In the current study, the authors sought to characterize BCs developing in a large cohort of women with BBD.

METHODS:

The current study cohort included 13,485 women who underwent breast biopsy for mammographic or palpable concerns between 1967 and 2001. Biopsy slides were reviewed and classified as nonproliferative disease, proliferative disease without atypia, or atypical hyperplasia. BCs were identified by follow-up questionnaires, medical records, and Tumor Registry data. BC tissues were obtained and reviewed.

RESULTS:

With median follow-up of 15.8 years, 1273 women developed BC. The majority of BCs were invasive (81%), of which 61% were ductal, 13% were mixed ductal/lobular, and 14% were lobular. Approximately two-thirds of the BC cases were intermediate or high grade, and 29% were lymph node positive. Cancer characteristics were similar across the 3 histologic categories of BBD, with a similar frequency of ductal carcinoma in situ, invasive disease, tumor size, time to invasive BC, histologic type of BC, lymph node positivity, and human epidermal growth factor receptor 2 positivity. Women with atypical hyperplasia were found to have a higher frequency of estrogen receptor-positive BC (91%) compared with women with proliferative disease without atypia (80%) or nonproliferative disease (85%) (P = .02).

CONCLUSIONS:

A substantial percentage of all BCs develop in women with prior BBD. The majority of BCs after BBD are invasive tumors of ductal type, with a substantial number demonstrating lymph node positivity. Of all the BCs in the current study, 84% were estrogen receptor positive. Prevention therapy should be strongly encouraged in higher-risk women with BBD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lesiones Precancerosas / Biopsia / Mama / Neoplasias de la Mama / Biomarcadores de Tumor / Ganglios Linfáticos Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Cancer Año: 2016 Tipo del documento: Article Pais de publicación: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lesiones Precancerosas / Biopsia / Mama / Neoplasias de la Mama / Biomarcadores de Tumor / Ganglios Linfáticos Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Cancer Año: 2016 Tipo del documento: Article Pais de publicación: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA