[Effects of Different Dose of Cyclophosphamide on Peripheral Blood Cells of Normal ICR Mice].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
; 23(5): 1493-6, 2015 Oct.
Article
en Zh
| MEDLINE
| ID: mdl-26524064
ABSTRACT
OBJECTIVE:
To investigate effective doses of cyclophosphamide (CTX) for establishment of leukopenia model in ICR mouse.METHODS:
Normal ICR mice (n = 96) were divided into CTX(80), CTX(100), CTX(120), CTX(150) and CTX(300) groups, of which mice received CTX intraperitoneally at a dose of 80, 100, 120, or 150 mg/kg once a day for 3 consecutive days, or 300 mg/kg with single injection. The peripheral blood cell counts were detected at various times before and after CTX administration.RESULTS:
The peripheral white blood cell nadirs in the mice injected with CTX appeared on day 4 after the first dose of CTX. The peripheral white blood cell nadir in group CTX(100) was 26.7% of the value measured in mice before CTX administrated, and that of group CTX(80) was 35.0%. Higher doses of CTX, however, caused too severity in hematopoietic injury.CONCLUSION:
The dose of CTX 100 mg/(kg·d) × 3d is appropriate for leucopenia model of ICR mouse.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ciclofosfamida
/
Leucocitos
Límite:
Animals
Idioma:
Zh
Revista:
Zhongguo Shi Yan Xue Ye Xue Za Zhi
Asunto de la revista:
HEMATOLOGIA
Año:
2015
Tipo del documento:
Article
País de afiliación:
China