Alkyne Carbonyl Metathesis As a Means To Make 4-Acyl Chromenes: Syntheses of (±)-Deguelin and (±)-Munduserone.
J Org Chem
; 80(22): 11460-7, 2015 Nov 20.
Article
en En
| MEDLINE
| ID: mdl-26525067
ABSTRACT
A highly convergent synthetic approach to rotenoid natural products is described. Successful pairing of two building blocks for Sonogashira cross-coupling and intramolecular alkyne carbonyl metathesis allows ready access to 4-acylchromene, a key substructure of these natural products, leading to syntheses of (±)-deguelin and (±)-munduserone in high overall yields.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Rotenona
/
Productos Biológicos
/
Alquinos
Idioma:
En
Revista:
J Org Chem
Año:
2015
Tipo del documento:
Article