Core chemotype diversification in the HIV-1 entry inhibitor class using field-based bioisosteric replacement.
Bioorg Med Chem Lett
; 26(1): 228-34, 2016 Jan 01.
Article
en En
| MEDLINE
| ID: mdl-26531151
ABSTRACT
Demand remains for new inhibitors of HIV-1 replication and the inhibition of HIV-1 entry is an extremely attractive therapeutic approach. Using field-based bioisosteric replacements, we have further extended the chemotypes available for development in the HIV-1 entry inhibitor class. Moreover, using field-based disparity analysis of the compounds, 3D structure-activity relationships were derived that will be useful in the further development of these inhibitors towards clinical utility.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
VIH-1
/
Fármacos Anti-VIH
/
Internalización del Virus
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos