Utility of flow cytometric κ and λ light chain analysis of peripheral blood.
J BUON
; 20(5): 1322-6, 2015.
Article
en En
| MEDLINE
| ID: mdl-26537081
ABSTRACT
PURPOSE:
Monoclonality in the peripheral blood can be shown by flow cytometric analysis of kappa (κ) and lambda (λ) light chain ratio of B lymphocytes. We aimed to show the utility of this method in patients with unknown causes of lymphadenopathy and/or splenomegaly.METHODS:
This method was performed in 81 adult patients with undefined causes of lymphadenopathy and splenomegaly.RESULTS:
18 (22%) of these patients had clonality and all of them were diagnosed as B cell lymphoma later. None of the patients with benign causes had clonality in the peripheral blood. We could not find any relationship between presence of clonality and type and stage of lymphoma and bone marrow involvement.CONCLUSION:
This method is easy to perform, cheap and non-invasive and yet it can give valuable information about the malignant nature of a suspected disease. If there is a sign of clonality in the peripheral blood, more invasive diagnostic procedures should be performed rather than watch and wait.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Linfoma de Células B
/
Cadenas kappa de Inmunoglobulina
/
Cadenas lambda de Inmunoglobulina
/
Citometría de Flujo
Límite:
Adult
/
Humans
Idioma:
En
Revista:
J BUON
Asunto de la revista:
NEOPLASIAS
Año:
2015
Tipo del documento:
Article
País de afiliación:
Turquía