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Diallyl trisulfide inhibits naphthalene-induced oxidative injury and the production of inflammatory responses in A549 cells and mice.
Zhang, Fang; Zhang, Yongchun; Wang, Kaiming; Zhu, Xiaosong; Lin, Guimei; Zhao, Zhongxi; Li, Shanzhong; Cai, Jianhua; Cao, Jimin.
Afiliación
  • Zhang F; School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan 250012, PR China.
  • Zhang Y; School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan 250012, PR China; School of Chemistry and Pharmaceutical Engineering, Qilu University of Technology, Daxue Road, Western University Science Park, Jinan, Shandong 250353, PR China.
  • Wang K; School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan 250012, PR China.
  • Zhu X; School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan 250012, PR China.
  • Lin G; School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan 250012, PR China.
  • Zhao Z; School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan 250012, PR China; Jiangsu Shengshi Kangde Biotech Corporation, Lianyungang, Jiangsu 222006, PR China. Electronic address: uszxzhao@gmail.com.
  • Li S; Jiangsu Shengshi Kangde Biotech Corporation, Lianyungang, Jiangsu 222006, PR China.
  • Cai J; Jiangsu Shengshi Kangde Biotech Corporation, Lianyungang, Jiangsu 222006, PR China.
  • Cao J; Jiangsu Shengshi Kangde Biotech Corporation, Lianyungang, Jiangsu 222006, PR China.
Int Immunopharmacol ; 29(2): 326-333, 2015 Dec.
Article en En | MEDLINE | ID: mdl-26548347
Diallyl trisulfide (DATS) is a garlic organosulfide that may have a therapeutic potential in the treatment of some diseases. We sought to determine whether DATS could inhibit naphthalene-induced oxidative injury and the production of inflammatory responses in vitro and in vivo. A549 cells were either pre-treated (PreTx, prevention) or concurrently treated (CoTx, treatment) with 20µM naphthalene and either 5 or 10µM DATS. PreTx and CoTx showed the prevention and the treatment potential of DATS to inhibit the generation of naphthalene-induced reactive oxygen species (ROS) in the A549 cells. DATS showed antioxidative activity by elevating the SOD activities in the low dose groups. The mechanistic study showed that the DATS-mediated inhibition of naphthalene-induced oxidative injury and the production of inflammatory responses (i.e., TNF-α, IL-6, and IL-8) were attributed to inhibiting the activity of nuclear factor-kappa B (NF-κB). In addition, DATS inhibited the production of serum nitric oxide NO and myeloperoxidase (MPO) in the lungs of Kunming mice. The histological analysis results indicate that DATS inhibited the naphthalene-induced lung damage, which is consistent with the in vitro study results. The in vivo and in vitro results suggest that DATS may be an effective attenuator of naphthalene-induced lung damage.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sulfuros / Estrés Oxidativo / Compuestos Alílicos / Antiinflamatorios / Naftalenos / Antioxidantes Límite: Animals Idioma: En Revista: Int Immunopharmacol Asunto de la revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Año: 2015 Tipo del documento: Article Pais de publicación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sulfuros / Estrés Oxidativo / Compuestos Alílicos / Antiinflamatorios / Naftalenos / Antioxidantes Límite: Animals Idioma: En Revista: Int Immunopharmacol Asunto de la revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Año: 2015 Tipo del documento: Article Pais de publicación: Países Bajos