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Antibody Persistence 1-5 Years Following Vaccination With MenAfriVac in African Children Vaccinated at 12-23 Months of Age.
Tapia, Milagritos D; Findlow, Helen; Idoko, Olubukola T; Preziosi, Marie-Pierre; Kulkarni, Prasad S; Enwere, Godwin C; Elie, Cheryl; Parulekar, Varsha; Sow, Samba O; Haidara, Fadima Cheick; Diallo, Fatoumata; Doumbia, Moussa; Akinsola, Adebayo K; Adegbola, Richard A; Kampmann, Beate; Chaumont, Julie; Martellet, Lionel; Marchetti, Elisa; Viviani, Simonetta; Tang, Yuxiao; Plikaytis, Brian D; LaForce, F Marc; Carlone, George; Borrow, Ray.
Afiliación
  • Tapia MD; Department of Pediatrics, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore.
  • Findlow H; Vaccine Evaluation Unit, Public Health England, Manchester Royal Infirmary, United Kingdom.
  • Idoko OT; Vaccines and Immunity Theme, Medical Research Council Unit, Basse, The Gambia.
  • Preziosi MP; Meningitis Vaccine Project, PATH, Ferney-Voltaire, France Meningitis Vaccine Project, Department of Immunization, Vaccines and Biologicals, World Health Organization, Geneva, Switzerland.
  • Kulkarni PS; Serum Institute of India, Ltd, Pune.
  • Enwere GC; Meningitis Vaccine Project, PATH, Ferney-Voltaire, France.
  • Elie C; Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Parulekar V; DiagnoSearch Life Sciences, Mumbai, India.
  • Sow SO; Centre pour le Développement des Vaccins, Ministère de la Santé, Bamako, Mali.
  • Haidara FC; Centre pour le Développement des Vaccins, Ministère de la Santé, Bamako, Mali.
  • Diallo F; Centre pour le Développement des Vaccins, Ministère de la Santé, Bamako, Mali.
  • Doumbia M; Centre pour le Développement des Vaccins, Ministère de la Santé, Bamako, Mali.
  • Akinsola AK; Vaccines and Immunity Theme, Medical Research Council Unit, Basse, The Gambia.
  • Adegbola RA; GlaxoSmithKline Vaccines, Wavre, Belgium.
  • Kampmann B; Vaccines and Immunity Theme, Medical Research Council Unit, Basse, The Gambia.
  • Chaumont J; Meningitis Vaccine Project, PATH, Ferney-Voltaire, France.
  • Martellet L; Meningitis Vaccine Project, PATH, Ferney-Voltaire, France.
  • Marchetti E; Meningitis Vaccine Project, PATH, Ferney-Voltaire, France.
  • Viviani S; Meningitis Vaccine Project, PATH, Ferney-Voltaire, France.
  • Tang Y; Meningitis Vaccine Project, PATH, Seattle, WA.
  • Plikaytis BD; Centers for Disease Control and Prevention, Atlanta, Georgia.
  • LaForce FM; Serum Institute of India, Ltd, Pune.
  • Carlone G; Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Borrow R; Vaccine Evaluation Unit, Public Health England, Manchester Royal Infirmary, United Kingdom.
Clin Infect Dis ; 61 Suppl 5: S514-20, 2015 Nov 15.
Article en En | MEDLINE | ID: mdl-26553683
BACKGROUND: Following mass vaccination campaigns in the African meningitis belt with group A meningococcal conjugate vaccine, MenAfriVac (PsA-TT), disease due to group A meningococci has nearly disappeared. Antibody persistence in healthy African toddlers was investigated. METHODS: African children vaccinated at 12-23 months of age with PsA-TT were followed for evaluation of antibody persistence up to 5 years after primary vaccination. Antibody persistence was evaluated by measuring group A serum bactericidal antibody (SBA) with rabbit complement and by a group A-specific IgG enzyme-linked immunosorbent assay (ELISA). RESULTS: Group A antibodies measured by SBA and ELISA were shown to decline in the year following vaccination and plateaued at levels significantly above baseline for up to 5 years following primary vaccination. CONCLUSIONS: A single dose of PsA-TT induces long-term sustained levels of group A meningococcal antibodies for up to 5 years after vaccination. CLINICAL TRIALS REGISTRATION: ISRTCN78147026.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Actividad Bactericida de la Sangre / Vacunas Meningococicas / Anticuerpos Antibacterianos Tipo de estudio: Observational_studies / Prognostic_studies Límite: Animals / Female / Humans / Infant / Male País/Región como asunto: Africa Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Actividad Bactericida de la Sangre / Vacunas Meningococicas / Anticuerpos Antibacterianos Tipo de estudio: Observational_studies / Prognostic_studies Límite: Animals / Female / Humans / Infant / Male País/Región como asunto: Africa Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos