[Age dynamics of angiogenesis markers in transgenic HER-2/neu (FBV/N) mammary adenocarcinoma-prone mice].
Vopr Onkol
; 61(4): 642-6, 2015.
Article
en Ru
| MEDLINE
| ID: mdl-26571837
ABSTRACT
Age-dependent angiogenesis intensity changes have been studied in transgenic HER-2/neu (FBV/N) mice characteristic of breast tumors' high incidence with hyperexpression of HER-2/neu. Concentration of vascular endothelial growth factor, insulin-dependent growth factor 1, nitrogen monoxide, tissue plasminogen activator and type 1 plasminogen activator inhibitor were assessed by means of immune-enzyme assay. The results testify to angiogenesis processes activation side by side with aging and growth of the tumors. Maximum manifestation of these disturbances (growth factors' blood concentrations increase and endotheliocytes' functional activity inhibition) has been revealed in 6-month-old mice during neoplasma maximum intensive and aggressive growth period.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Envejecimiento
/
Adenocarcinoma
/
Biomarcadores de Tumor
/
Neoplasias Mamarias Animales
/
Receptor ErbB-2
/
Neovascularización Patológica
Límite:
Animals
Idioma:
Ru
Revista:
Vopr Onkol
Año:
2015
Tipo del documento:
Article