Recurrent pre-eclampsia in women with metabolic syndrome and low plasma volume: a retrospective cohort study.
BJOG
; 122(13): 1773-80, 2015 Dec.
Article
en En
| MEDLINE
| ID: mdl-26589850
ABSTRACT
OBJECTIVE:
To determine the prevalence of recurrent pre-eclampsia in women with a history of pre-eclampsia with both metabolic syndrome and low plasma volume postpartum, as compared with women without either entity.DESIGN:
Retrospective cohort study.SETTING:
Three tertiary referral hospitals in the Netherlands. POPULATION Women with a history of pre-eclampsia.METHODS:
In 196 women with a history of pre-eclampsia we determined the presence or absence of metabolic syndrome using the World Health Organization criteria and measured plasma volume with the (125) I-human serum albumin indicator dilution technique. We compared the prevalence of recurrent pre-eclampsia in four groups, classified according to presence or absence of metabolic syndrome and low or normal plasma volume, calculating odds ratios (OR), adjusted for confounders. MAIN OUTCOMEMEASURE:
Recurrence of pre-eclampsia in the subsequent pregnancy.RESULTS:
The prevalence of recurrent pre-eclampsia was 12% (12/99) in women without metabolic syndrome with normal plasma volume, versus 47% (8/17) in women with both metabolic syndrome and low plasma volume OR 6.44 (95% CI 2.09-19.90), adjusted OR 7.90 (95% CI 2.30-27.16). Recurrent pre-eclampsia was present in 44% (10/23) and 25% (14/57) of women with isolated metabolic syndrome and low plasma volume, respectively.CONCLUSIONS:
In the concomitant presence of metabolic syndrome and low plasma volume, the prevalence of recurrent pre-eclampsia was nearly 50%, which is four times as high as the prevalence in women without either entity. TWEETABLE ABSTRACT Metabolic syndrome and low plasma volume raise the risk of recurrent pre-eclampsia to nearly 50%.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Volumen Plasmático
/
Preeclampsia
/
Síndrome Metabólico
/
Periodo Posparto
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Pregnancy
País/Región como asunto:
Europa
Idioma:
En
Revista:
BJOG
Asunto de la revista:
GINECOLOGIA
/
OBSTETRICIA
Año:
2015
Tipo del documento:
Article
País de afiliación:
Países Bajos