FCE 22101 and FCE 22891: in-vitro antibacterial activity at concentrations simulating human plasma levels following intravenous, intramuscular and oral administration.
J Antimicrob Chemother
; 23 Suppl C: 119-28, 1989 Mar.
Article
en En
| MEDLINE
| ID: mdl-2659570
ABSTRACT
The plasma concentrations of FCE 22101 observed following slow intravenous infusions (1 and 4 h), intramuscular injection and after oral administration of the prodrug FCE 22891 were simulated in a glass chamber containing bacterial cultures. The bacteria used were Staphylococcus aureus ATCC 13709, Staph. aureus 2101 (methicillin-resistant), Streptococcus faecium ATCC 8043, Escherichia coli ATCC 12407, Enterobacter cloacae 1321E and Ent. cloacae P99 (cefazolin-resistant). Addition of FCE 22101 was found to result in a reduction in number of all bacterial strains except Str. faecium, with which only bacteriostasis was observed.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bacterias
/
Carbapenémicos
/
Lactamas
/
Antibacterianos
Límite:
Humans
Idioma:
En
Revista:
J Antimicrob Chemother
Año:
1989
Tipo del documento:
Article
País de afiliación:
Italia