Synthesis of 5-Aminoimidazole-4-Carboxamide Riboside (AICAR) and Its Derivatives Using Inosine as Starting Material.
Curr Protoc Nucleic Acid Chem
; 63: 1.35.1-1.35.24, 2015 Dec 01.
Article
en En
| MEDLINE
| ID: mdl-26623971
ABSTRACT
This unit contains four basic protocols describing the synthesis of 5-aminoimidazole-4-carboxamide riboside (AICAR), 5-aminoimidazole-4-carboxamide riboside (ZPM), their 4-N functionalized derivatives, and two sugar-modified analogs of AICAR. The first and second basic protocols reveal the importance of solid-phase synthesis to obtain novel AICAR and ZMP imidazole-modified analogs in a short time, whereas the third and fourth basic protocols allow for the rapid preparation of 5'-F-AICAR and D-ribityl AICA.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ribonucleótidos
/
Aminoimidazol Carboxamida
/
Inosina
Idioma:
En
Revista:
Curr Protoc Nucleic Acid Chem
Año:
2015
Tipo del documento:
Article
País de afiliación:
Italia