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Cytotoxicity of electrophilic iron(II)-clathrochelates in human promyelocytic leukemia cell line.
Blechinger, Jenny; Varzackii, Oleg A; Kovalska, Vladyslava; Zelinskii, Genrikh E; Voloshin, Yan Z; Kinski, Elisa; Mokhir, Andriy.
Afiliación
  • Blechinger J; Friedrich-Alexander-University of Erlangen-Nürnberg, Department of Chemistry and Pharmacy, Organic Chemistry Chair II, Henkestr. 42, 91054 Erlangen, Germany.
  • Varzackii OA; Institute of General and Inorganic Chemistry NASU, 32/34 Palladin Av., 03680 Kyiv, Ukraine.
  • Kovalska V; Institute of Molecular Biology and Genetics NASU, 150, Zabolotnogo Str., 03143 Kyiv, Ukraine.
  • Zelinskii GE; Nesmeyanov Institute of the Organoelement Compounds RAS, Moscow, Russia.
  • Voloshin YZ; Nesmeyanov Institute of the Organoelement Compounds RAS, Moscow, Russia.
  • Kinski E; Friedrich-Alexander-University of Erlangen-Nürnberg, Department of Chemistry and Pharmacy, Organic Chemistry Chair II, Henkestr. 42, 91054 Erlangen, Germany.
  • Mokhir A; Friedrich-Alexander-University of Erlangen-Nürnberg, Department of Chemistry and Pharmacy, Organic Chemistry Chair II, Henkestr. 42, 91054 Erlangen, Germany.
Bioorg Med Chem Lett ; 26(2): 626-629, 2016 Jan 15.
Article en En | MEDLINE | ID: mdl-26631314
ABSTRACT
We observed that electrophilic iron(II)-clathrochelates exhibit significant cytotoxicity in human promyelocytic leukemia cells (IC50=6.5±4.6µM), which correlates with the enhancement of intracellular oxidative stress (17-fold increase with respect to the cells treated with the solvent only). Based on in vitro studies we suggested that this effect is caused by alkylation of glutathione leading to inhibition of the cellular antioxidative system and by catalytic generation of reactive oxygen species by products of the alkylation reaction.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos Ferrosos / Leucemia Promielocítica Aguda / Estrés Oxidativo / Células Precursoras de Granulocitos / Antineoplásicos Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos Ferrosos / Leucemia Promielocítica Aguda / Estrés Oxidativo / Células Precursoras de Granulocitos / Antineoplásicos Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Alemania