Psoriasis in melanoma patients: a prospective pilot study.
G Ital Dermatol Venereol
; 152(2): 109-116, 2017 Apr.
Article
en En
| MEDLINE
| ID: mdl-26632958
ABSTRACT
BACKGROUND:
Melanoma is an immunogenic tumor and the presence of T-cell infiltrates within melanoma lesions may correlated with longer patient survival. Psoriasis is a chronic immune-mediated inflammatory disease, in which the role of T-cells is well established. The aim of our prospective pilot study was to investigate the relationship between melanoma and psoriasis examining 3 groups of patients the melanoma-group (MG), the psoriasis-group (PG) and the control-group (CG).METHODS:
Every patient underwent detailed anamnestic and clinical examination. Moreover, gene expression of interleukin-6 (IL-6), interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) was analyzed in all groups and in subjects affected by both melanoma and psoriasis (MP).RESULTS:
Melanoma patients showed a lower frequency of psoriasis and positive family history (FH) of psoriasis respect to CG. Moreover, psoriatic patients presented fewer MN, and lower frequency of positive FH of melanoma than CG. IL-6 and IFN-γ were significantly increased in PG and reduced in MG.CONCLUSIONS:
We propose a provocative hypothesis of a possible protective role of psoriasis for melanoma development.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Psoriasis
/
Neoplasias Cutáneas
/
Regulación de la Expresión Génica
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Melanoma
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
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Aged
/
Aged80
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
G Ital Dermatol Venereol
Año:
2017
Tipo del documento:
Article
País de afiliación:
Italia