Elevated red cell distribution width contributes to a poor prognosis in patients with esophageal carcinoma.
Clin Chim Acta
; 452: 199-203, 2016 Jan 15.
Article
en En
| MEDLINE
| ID: mdl-26633854
ABSTRACT
BACKGROUND:
The red cell distribution width (RDW) has also been reported to reliably reflect the inflammation and nutrition status and predict the prognosis across several types of cancer, however, the prognostic value of RDW in esophageal carcinoma has seldom been studied.METHODS:
A retrospective study was performed to assess the prognostic value of RDW in patients with esophageal carcinoma by the Kaplan-Meier analysis and multivariate Cox regression proportional hazard model. All enrolled patients were divided into high RDW group (â§15%) and low RDW group (<15%) according to the detected RDW values.RESULTS:
Clinical and laboratory data from a total of 179 patients with esophageal carcinoma were retrieved. With a median follow-up of 21months, the high RDW group exhibited a shorter disease-free survival (DFS) (p<0.001) and an unfavorable overall survival (OS) (p<0.001) in the univariate analysis. The multivariate analysis revealed that elevated RDW at diagnosis was an independent prognostic factor for shorter PFS (p=0.043, HR=1.907, 95% CI=1.020-3.565) and poor OS (p=0.042, HR=1.895, 95% CI=1.023-3.508) after adjustment with other cancer-related prognostic factors.CONCLUSION:
The present study suggests that elevated preoperative RDW(â§15%) at the diagnosis may independently predict poorer disease-free and overall survival among patients with esophageal carcinoma.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Esofágicas
/
Índices de Eritrocitos
Tipo de estudio:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Clin Chim Acta
Año:
2016
Tipo del documento:
Article
País de afiliación:
China