[Correction of Metabolic Processes in Rats during Chronic Endotoxicosis using Isotope (D/H) Exchange Reactions].
Izv Akad Nauk Ser Biol
; (5): 518-27, 2015.
Article
en Ru
| MEDLINE
| ID: mdl-26638240
ABSTRACT
The effect of isotope exchange reactions (deuterium/protium, D/H) on morphofunctional indices and the state of the antioxidant blood system in rats was studied under physiological conditions and during experimental chronic endotoxicosis of hepatorenal genesis. It was demonstrated that introduction of water with a decreased content of deuterium in the food rations of rats results in a decrease in its concentration in the blood plasma by 32-36% (to 98-106 ppm) and in lyophilized liver, kidney, and heart tissues by 13-17% (to 123-128 ppm). It was noted that it is accompanied by correction of metabolic processes, an increase in the functional activity of nonspecific protection system, and an increase in the body weight growth by the 42nd day in the group of animals that passed (for 14 days) the stage of preliminary adaptation with a change in the D/H ratio in the organism.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Endotoxemia
/
Medición de Intercambio de Deuterio
/
Antioxidantes
Límite:
Animals
Idioma:
Ru
Revista:
Izv Akad Nauk Ser Biol
Asunto de la revista:
BIOLOGIA
Año:
2015
Tipo del documento:
Article