Thymic Involution in Ontogenesis: Role in Aging Program.
Biochemistry (Mosc)
; 80(12): 1629-31, 2015 Dec.
Article
en En
| MEDLINE
| ID: mdl-26638690
ABSTRACT
In most mammals, involution of the thymus occurs with aging. In this issue of Biochemistry (Moscow) devoted to phenoptosis, A. V. Khalyavkin considered involution of a thymus as an example of the program of development and further--of proliferation control and prevention of tumor growth. However, in animals devoid of a thymus (e.g. naked mice), stimulation of carcinogenesis, but not its prevention was observed. In this report, we focus on the involution of the thymus as a manifestation of the aging program (slow phenoptosis). We also consider methods of reversal/arrest of this program at different levels of organization of life (cell, tissue, and organism) including surgical manipulations, hormonal effects, genetic techniques, as well as the use of conventional and mitochondria-targeted antioxidants. We conclude that programmed aging (at least on the model of age-dependent thymic atrophy) can be inhibited.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Timo
/
Envejecimiento
Límite:
Animals
Idioma:
En
Revista:
Biochemistry (Mosc)
Año:
2015
Tipo del documento:
Article
País de afiliación:
Rusia