THE EFFECT OF SEROTONIN 5-HT1A, 5-HT2 RECEPTOR LIGANDS, KETOPROFEN AND THEIR COMBINATION IN MODELS OF INDUCED PAIN IN MICE.
Acta Pol Pharm
; 72(3): 579-85, 2015.
Article
en En
| MEDLINE
| ID: mdl-26642666
The present study was carried out to investigate the effects of the 7-(3-chlorophenyl)piperazinylalkyl derivatives of 8-alkoxypurine-2,6-dione (compounds 1-4) in two animal models of induced pain and to compare their effects with ketoprofen and with their combination. All experiments were performed on albino mice. Mice were evaluated for their responsiveness to noxious stimuli using: the hot-plate test and the phenylbenzo-quinone-induced writhing test. All compounds showed analgesic activity only in the writhing test. The analgesic activities of compounds 3 and 4 were similar to ketoprofen. The compounds slightly increased the analgesic effect of ketoprofen when used in combination in the visceral type of pain. The possible mechanisms of the antinociceptive effect of these compounds are thought to involve the activation of analgesic effect mediated by the serotonergic pathways or combination of this mechanism with other important mediators playing a role in pain modulation.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Dolor
/
Cetoprofeno
/
Receptor de Serotonina 5-HT1A
/
Receptores de Serotonina 5-HT2
/
Analgésicos
Límite:
Animals
Idioma:
En
Revista:
Acta Pol Pharm
Año:
2015
Tipo del documento:
Article
Pais de publicación:
Polonia