[Efficacy of polyprenyl phosphates in the experimental genital herpes model].
Vopr Virusol
; 60(4): 9-13, 2015.
Article
en Ru
| MEDLINE
| ID: mdl-26665428
An experimental model of the primary genital herpes (herpes simplex type 2, HSV-2) in the female guinea pigs was suggested to study the infectious process activity of polyprenyl phosphates (PPP) and PPP+acyclovir (AC) complex treatment. The morphofunctional features of the guinea pig ovaries were studied in the control and experimental groups (the latter were inoculated with PPP and/or AC as a primary infection treatment) at the stage of the recurrent genital herpes aggravation. It was shown that in the case of combined PPP +AC use significant changes in the disease symptoms were observed, as well as a decrease in the infectious process activity and duration, and positive remote effect on the ovarian morphophysiology.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antivirales
/
Fosfatos de Poliisoprenilo
/
Aciclovir
/
Herpes Genital
/
Herpesvirus Humano 2
Límite:
Animals
/
Female
/
Humans
Idioma:
Ru
Revista:
Vopr Virusol
Año:
2015
Tipo del documento:
Article
Pais de publicación:
Rusia