The Dynamics of HPV Infection and Cervical Cancer Cells.
Bull Math Biol
; 78(1): 4-20, 2016 Jan.
Article
en En
| MEDLINE
| ID: mdl-26676766
ABSTRACT
The development of cervical cells from normal cells infected by human papillomavirus into invasive cancer cells can be modeled using population dynamics of the cells and free virus. The cell populations are separated into four compartments susceptible cells, infected cells, precancerous cells and cancer cells. The model system of differential equations also has a free virus compartment in the system, which infect normal cells. We analyze the local stability of the equilibrium points of the model and investigate the parameters, which play an important role in the progression toward invasive cancer. By simulation, we investigate the boundary between initial conditions of solutions, which tend to stable equilibrium point, representing controlled infection, and those which tend to unbounded growth of the cancer cell population. Parameters affected by drug treatment are varied, and their effect on the risk of cancer progression is explored.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Papillomaviridae
/
Neoplasias del Cuello Uterino
/
Infecciones por Papillomavirus
/
Modelos Biológicos
Límite:
Female
/
Humans
Idioma:
En
Revista:
Bull Math Biol
Año:
2016
Tipo del documento:
Article
País de afiliación:
Indonesia